The neuroprotective effect of melatonin in glutamate excitotoxicity of R28 cells and mouse retinal ganglion cells

Glaucoma is the leading cause of irreversible blindness.The progressive degeneration of retinal ganglion cells (RGCs) is the major characteristic of Front Closure Bras glaucoma.Even though the control of intraocular pressure could delay the loss of RGCs, current clinical treatments cannot protect them directly.The overactivation of N-methyl-D-aspar

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DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells

Abstract Age-related depletion of stem cells causes tissue degeneration and failure to tissue regeneration, driving aging at the organismal level.Previously we reported a cell-non-autonomous DAF-16/FOXO activity in antagonizing the age-related loss of germline stem/progenitor cells (GSPCs) D-GLUCOSAMINE in C.elegans, indicating that regulation of s

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